Identification and activity of inhibitors of the essential nematode-specific metalloprotease DPY-31

Infection by parasitic nematodes is widespread in the developing world causing extensive morbidity and mortality. Furthermore, infection of animals is a global problem, with a substantial impact on food production. Here we identify small molecule inhibitors of a nematode-specific metalloprotease, DP...

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Publicado en:Bioorg Med Chem Lett
Main Authors: France, David J., Stepek, Gillian, Houston, Douglas R., Williams, Lewis, McCormack, Gillian, Walkinshaw, Malcolm D., Page, Antony P.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Science Ltd 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658336/
https://ncbi.nlm.nih.gov/pubmed/26546217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.10.077
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