P2Y(12) Receptor Localizes in the Renal Collecting Duct and Its Blockade Augments Arginine Vasopressin Action and Alleviates Nephrogenic Diabetes Insipidus

P2Y(12) receptor (P2Y(12)-R) signaling is mediated through G(i), ultimately reducing cellular cAMP levels. Because cAMP is a central modulator of arginine vasopressin (AVP)-induced water transport in the renal collecting duct (CD), we hypothesized that if expressed in the CD, P2Y(12)-R may play a ro...

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Bibliografske podrobnosti
izdano v:J Am Soc Nephrol
Main Authors: Zhang, Yue, Peti-Peterdi, Janos, Müller, Christa E., Carlson, Noel G., Baqi, Younis, Strasburg, David L., Heiney, Kristina M., Villanueva, Karie, Kohan, Donald E., Kishore, Bellamkonda K.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2015
Teme:
Basic Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657822/
https://ncbi.nlm.nih.gov/pubmed/25855780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014010118
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