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Evaluating State Dependence and Subtype Selectivity of Calcium Channel Modulators in Automated Electrophysiology Assays

Voltage-gated Ca(2+) channels play essential roles in control of neurosecretion and muscle contraction. The pharmacological significance of Ca(v) channels stem from their identification as the molecular targets of calcium blockers used in the treatment of cardiovascular diseases, such as hypertensio...

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Publicado en:Assay Drug Dev Technol
Main Authors: Kuryshev, Yuri A., Brown, Arthur M., Duzic, Emir, Kirsch, Glenn E.
Formato: Artigo
Idioma:Inglês
Publicado: Mary Ann Liebert, Inc. 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657039/
https://ncbi.nlm.nih.gov/pubmed/24579774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2013.552
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