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Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

Inhibition of cancer-promoting kinases is an established therapeutic strategy for the treatment of many cancers, although resistance to kinase inhibitors is common. One way to overcome resistance is to target orthogonal cancer-promoting pathways. Bromo and Extra-Terminal (BET) domain proteins, which...

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書目詳細資料
發表在:Sci Rep
Main Authors: Allen, Bryce K., Mehta, Saurabh, Ember, Stewart W. J., Schonbrunn, Ernst, Ayad, Nagi, Schürer, Stephan C.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657038/
https://ncbi.nlm.nih.gov/pubmed/26596901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16924
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