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Mutational characteristics in consecutive passage of rapidly replicating variants of hepatitis A virus strain H2 during cell culture adaptation

AIM: To investigate the molecular mechanism of cell adaptation and rapid replication of hepatitis A virus strain H2 in KBM17 cells. METHODS: Virus of strain H2 at passage 7 was consecutively passaged in KBM17 cells for 22 passages, every passage was incubated for 14 d. Antigenic and infectious titer...

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Bibliografski detalji
Izdano u:World J Gastroenterol
Glavni autori: Hu, Ning-Zhu, Hu, Yun-Zhang, Shi, Hai-Jing, Liu, Guo-Dong, Qu, Su
Format: Artigo
Jezik:Inglês
Izdano: Baishideng Publishing Group Inc 2002
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656578/
https://ncbi.nlm.nih.gov/pubmed/12378633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v8.i5.872
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