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ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction

In addition to triacylglycerols, adipocytes contain a large reserve of unesterified cholesterol. During adipocyte lipolysis and cell death seen during severe obesity and weight loss, free fatty acids and cholesterol become available for uptake and processing by adipose tissue macrophages (ATMs). We...

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Dettagli Bibliografici
Pubblicato in:J Lipid Res
Autori principali: Wei, Hao, Tarling, Elizabeth J., McMillen, Timothy S., Tang, Chongren, LeBoeuf, Renée C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655989/
https://ncbi.nlm.nih.gov/pubmed/26489644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M063354
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