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Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis
Human carbamoyl phosphate synthetase (CPS1), a 1500-residue multidomain enzyme, catalyzes the first step of ammonia detoxification to urea requiring N-acetyl-L-glutamate (NAG) as essential activator to prevent ammonia/amino acids depletion. Here we present the crystal structures of CPS1 in the absen...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4655335/ https://ncbi.nlm.nih.gov/pubmed/26592762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16950 |
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