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Caspase-3 cleaved p65 fragment dampens NF-κB-mediated anti-apoptotic transcription by interfering with the p65/RPS3 interaction

Caspase-3-mediated p65 cleavage is believed to suppress nuclear factor-kappa B (NF-κB)-mediated anti-apoptotic transactivation in cells undergoing apoptosis. However, only a small percentage of p65 is cleaved during apoptosis, not in proportion to the dramatic reduction in NF-κB transactivation. Her...

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發表在:FEBS Lett
Main Authors: Wier, Eric M., Fu, Kai, Hodgson, Andrea, Sun, Xin, Wan, Fengyi
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655178/
https://ncbi.nlm.nih.gov/pubmed/26526615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2015.10.019
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