Dual allosteric modulation of opioid antinociceptive potency by a(2A)-adrenoceptors

Opioid and α(2)-adrenoceptor (AR) agonists are analgesic when administered in the spinal cord and show a clinically beneficial synergistic interaction when co-administered. However, α(2)-AR antagonists can also inhibit opioid antinociception, suggesting a complex interaction between the two systems....

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Detalhes bibliográficos
Publicado no:Neuropharmacology
Main Authors: Chabot-Doré, Anne-Julie, Millecamps, Magali, Naso, Lina, Devost, Dominic, Trieu, Phan, Piltonen, Marjo, Diatchenko, Luda, Fairbanks, Carolyn A., Wilcox, George L., Hébert, Terence E., Stone, Laura S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655173/
https://ncbi.nlm.nih.gov/pubmed/26254859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2015.08.010
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