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Central tolerance to self revealed by the autoimmune regulator
The autoimmune regulator (Aire) was initially identified as the gene causing multiorgan system autoimmunity in humans, and deletion of this gene in mice also resulted in organ-specific autoimmunity. Aire regulates the expression of tissue-specific antigens (TSAs) in medullary thymic epithelial cells...
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| Udgivet i: | Ann N Y Acad Sci |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4654700/ https://ncbi.nlm.nih.gov/pubmed/26579596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.12960 |
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