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Central tolerance to self revealed by the autoimmune regulator
The autoimmune regulator (Aire) was initially identified as the gene causing multiorgan system autoimmunity in humans, and deletion of this gene in mice also resulted in organ-specific autoimmunity. Aire regulates the expression of tissue-specific antigens (TSAs) in medullary thymic epithelial cells...
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| Publicado no: | Ann N Y Acad Sci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4654700/ https://ncbi.nlm.nih.gov/pubmed/26579596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.12960 |
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