Type 1 interferon-induced IL-7 maintains CD8(+) T-cell responses and homeostasis by suppressing PD-1 expression in viral hepatitis

Type 1 interferon (IFN-I) promotes antigen-presenting cell maturation and was recently shown to induce hepatic IL-7 production during infection. Herein, we further explored the underlying mechanisms used by IFN-I to orchestrate antiviral immune responses in the liver. Acute viral hepatitis was induc...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Mol Immunol
Main Authors: Hou, Lifei, Jie, Zuliang, Liang, Yuejin, Desai, Mayura, Soong, Lynn, Sun, Jiaren
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654295/
https://ncbi.nlm.nih.gov/pubmed/25027969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2014.49
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