A point mutation of the Na+/H+ exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis.

Gelijkaardige items

• Functional characteristics of a cloned epithelial Na+/H+ exchanger (NHE3): resistance to amiloride and inhibition by protein kinase C.
  door: Tse, C M, et al.
  Gepubliceerd in: (1993)
• Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation.
  door: Pouysségur, J, et al.
  Gepubliceerd in: (1982)
• Detection of rare point mutation via allele-specific amplification in emulsion PCR
  door: Cheng, Changming, et al.
  Gepubliceerd in: (2013)
• A mechanism for the activation of the Na/H exchanger NHE-1 by cytoplasmic acidification and mitogens
  door: Lacroix, Jérôme, et al.
  Gepubliceerd in: (2004)
• The cytoplasmic domain of the Na+/H+ exchangers (NHEs) dictates the nature of the hormonal response: behavior of a chimeric human NHE1/trout beta NHE antiporter.
  door: Borgese, F, et al.
  Gepubliceerd in: (1994)