PKR deficiency alters E. coli-induced sickness behaviors but does not exacerbate neuroimmune responses or bacterial load

BACKGROUND: Systemic inflammation induces neuroimmune activation, ultimately leading to sickness (e.g., fever, anorexia, motor impairments, exploratory deficits, and social withdrawal). In this study, we evaluated the role of protein kinase R (PKR), a serine-threonine kinase that can control systemi...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Poon, David Chun-Hei, Ho, Yuen-Shan, You, Ran, Tse, Hei-Long, Chiu, Kin, Chang, Raymond Chuen-Chung
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653925/
https://ncbi.nlm.nih.gov/pubmed/26585788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0433-2
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