Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations

Functional variability at the arylamine N-acetyltransferase genes is associated with drug response in humans and may have been adaptive in the past owing to selection pressure from diet and exposure to toxins during human evolution. AIMS: We have characterized nucleotide variation at the NAT1 and NA...

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Pubblicato in:Pharmacogenomics
Autori principali: Mortensen, Holly M, Froment, Alain, Lema, Godfrey, Bodo, Jean-Marie, Ibrahim, Muntaser, Nyambo, Thomas B, Omar, Sabah A, Tishkoff, Sarah A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653814/
https://ncbi.nlm.nih.gov/pubmed/21995608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.11.88
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