Sphingosine-1-phosphate inhibits IL-1–induced expression of C-C motif ligand 5 via c-Fos–dependent suppression of IFN-β amplification loop

The neuroinflammation associated with multiple sclerosis involves activation of astrocytes that secrete and respond to inflammatory mediators such as IL-1. IL-1 stimulates expression of many chemokines, including C-C motif ligand (CCL) 5, that recruit immune cells, but it also stimulates sphingosine...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Yester, Jessie W., Bryan, Lauren, Waters, Michael R., Mierzenski, Bartosz, Biswas, Debolina D., Gupta, Angela S., Bhardwaj, Reetika, Surace, Michael J., Eltit, Jose M., Milstien, Sheldon, Spiegel, Sarah, Kordula, Tomasz
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2015
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653053/
https://ncbi.nlm.nih.gov/pubmed/26246404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-275180
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