Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel tumor suppressor microRNA, in cutaneous T-Cell lymphoma

Aberrant activation of Janus kinase-3 (Jak3) and its key down-stream effectors, Signal Transducer and Activator of Transcription-3 (STAT3) and STAT5, is a key feature of malignant transformation in cutaneous T-cell lymphoma (CTCL). However, it remains only partially understood how Jak3/STAT activati...

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Библиографические подробности
Опубликовано в: :Oncotarget
Главные авторы: Sibbesen, Nina A., Kopp, Katharina L., Litvinov, Ivan V., Jønson, Lars, Willerslev-Olsen, Andreas, Fredholm, Simon, Petersen, David L., Nastasi, Claudia, Krejsgaard, Thorbjørn, Lindahl, Lise M., Gniadecki, Robert, Mongan, Nigel P., Sasseville, Denis, Wasik, Mariusz A., Iversen, Lars, Bonefeld, Charlotte M., Geisler, Carsten, Woetmann, Anders, Odum, Niels
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2015
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653025/
https://ncbi.nlm.nih.gov/pubmed/26244872
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