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The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5′TOP sequence
La-related protein 1 (LARP1) regulates the stability of many mRNAs. These include 5′TOPs, mTOR-kinase responsive mRNAs with pyrimidine-rich 5′ UTRs, which encode ribosomal proteins and translation factors. We determined that the highly conserved LARP1-specific C-terminal DM15 region of human LARP1 d...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4652764/ https://ncbi.nlm.nih.gov/pubmed/26206669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv748 |
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