Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells

The plant flavonoid luteolin exhibits different biological effects, including anticancer properties. Little is known on the molecular mechanisms underlying its actions in colorectal cancer (CRC). Here we investigated the effects of luteolin on colon cancer cells, focusing on the balance between cera...

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Udgivet i:PLoS One
Main Authors: Abdel Hadi, Loubna, Di Vito, Clara, Marfia, Giovanni, Ferraretto, Anita, Tringali, Cristina, Viani, Paola, Riboni, Laura
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651545/
https://ncbi.nlm.nih.gov/pubmed/26580959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143384
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