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First-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer Agent

We previously identified ONC201 (TIC10) as a first-in-class orally active small molecule with robust antitumor activity that is currently in clinical trials in advanced cancers. Here, we further investigate the safety characteristics of ONC201 in preclinical models that reveal an excellent safety pr...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Allen, Joshua E., Crowder, Roslyn, El-Deiry, Wafik S.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651306/
https://ncbi.nlm.nih.gov/pubmed/26580220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143082
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