Therapeutic effects of DZ2002, a reversible SAHH inhibitor, on lupus-prone NZB×NZW F1 mice via interference with TLR-mediated APC response

AIM: To examine the therapeutic effects and underlying mechanisms of DZ2002, a reversible S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitor, on lupus-prone female NZB×NZW F1 (NZB/W F1) mice. METHODS: Female NZB/W F1 mice were treated orally with DZ2002 (0.5 mg·kg(−1)·d(−1)) for 11 weeks, and the...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: He, Shi-jun, Lin, Ze-min, Wu, Yan-wei, Bai, Bing-xin, Yang, Xiao-qian, He, Pei-lan, Zhu, Feng-hua, Tang, Wei, Zuo, Jian-ping
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651227/
https://ncbi.nlm.nih.gov/pubmed/24374810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.167
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