A Pilot Study Measuring the Distribution and Permeability of a Vaginal HIV Microbicide Gel Vehicle Using Magnetic Resonance Imaging, Single Photon Emission Computed Tomography/Computed Tomography, and a Radiolabeled Small Molecule

Vaginal microbicide gels containing tenofovir have proven effective in HIV prevention, offering the advantage of reduced systemic toxicity. We studied the vaginal distribution and effect on mucosal permeability of a gel vehicle. Six premenopausal women were enrolled. In Phase 1, a spreading gel cont...

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Vydáno v:AIDS Res Hum Retroviruses
Hlavní autoři: Fuchs, Edward J., Schwartz, Jill L., Friend, David R., Coleman, Jenell S., Hendrix, Craig W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2015
Témata:
Clinical Trials/Clinical Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651045/
https://ncbi.nlm.nih.gov/pubmed/26077739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2015.0054
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