Extended Loop Region of Hcp1 is Critical for the Assembly and Function of Type VI Secretion System in Burkholderia pseudomallei

The Type VI Secretion System cluster 1 (T6SS1) is essential for the pathogenesis of Burkholderia pseudomallei, the causative agent of melioidosis, a disease endemic in the tropics. Inside host cells, B. pseudomallei escapes into the cytosol and through T6SS1, induces multinucleated giant cell (MNGC)...

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Udgivet i:Sci Rep
Main Authors: Lim, Yan Ting, Jobichen, Chacko, Wong, Jocelyn, Limmathurotsakul, Direk, Li, Shaowei, Chen, Yahua, Raida, Manfred, Srinivasan, Nalini, MacAry, Paul Anthony, Sivaraman, J., Gan, Yunn-Hwen
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650826/
https://ncbi.nlm.nih.gov/pubmed/25648885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08235
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