Low-dose memantine attenuated methadone dose in opioid-dependent patients: a 12-week double-blind randomized controlled trial

Low-dose memantine might have anti-inflammatory and neurotrophic effects mechanistically remote from an NMDA receptor. We investigated whether add-on memantine reduced cytokine levels and benefitted patients with opioid dependence undergoing methadone maintenance therapy (MMT) in a randomized, doubl...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lee, Sheng-Yu, Chen, Shiou-Lan, Chang, Yun-Hsuan, Chen, Po See, Huang, San-Yuan, Tzeng, Nian-Sheng, Wang, Liang-Jen, Lee, I Hui, Wang, Tzu-Yun, Chen, Kao Chin, Yang, Yen Kuang, Hong, Jau-Shyong, Lu, Ru-Band
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650802/
https://ncbi.nlm.nih.gov/pubmed/25988317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10140
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