Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases

The His-x-Asp (HxD) motif is one of the most conserved structural components of the catalytic core of protein kinases; however, the functional role of the conserved histidine is unclear. Here we report that replacement of the HxD-histidine with Arginine or Phenylalanine in Aurora A abolishes both th...

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Publicado no:Sci Rep
Main Authors: Zhang, Lun, Wang, Jian-Chuan, Hou, Li, Cao, Peng-Rong, Wu, Li, Zhang, Qian-Sen, Yang, Huai-Yu, Zang, Yi, Ding, Jian-Ping, Li, Jia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650784/
https://ncbi.nlm.nih.gov/pubmed/25960268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10115
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