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Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases
The His-x-Asp (HxD) motif is one of the most conserved structural components of the catalytic core of protein kinases; however, the functional role of the conserved histidine is unclear. Here we report that replacement of the HxD-histidine with Arginine or Phenylalanine in Aurora A abolishes both th...
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| Foilsithe in: | Sci Rep |
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| Main Authors: | , , , , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Nature Publishing Group
2015
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4650784/ https://ncbi.nlm.nih.gov/pubmed/25960268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10115 |
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