Analysis of gene expression array in TSC2-deficient AML cells reveals IRF7 as a pivotal factor in the Rheb/mTOR pathway

Mutations in tuberous sclerosis (TSC) genes cause the genetic disorder TSC, as well as other neoplasms, including lymphangioleiomyomatosis (LAM) and angiomyolipomas (AMLs). AMLs are benign renal tumors occur both in sporadic LAM and in TSC. As they carry the same mutations, AML cell lines serve as a...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Makovski, V, Jacob-Hirsch, J, Gefen-Dor, C, Shai, B, Ehrlich, M, Rechavi, G, Kloog, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649829/
https://ncbi.nlm.nih.gov/pubmed/25476905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.502
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