Modulation of Macrophage Functional Polarity towards Anti-Inflammatory Phenotype with Plasmid DNA Delivery in CD44 Targeting Hyaluronic Acid Nanoparticles

The purpose of this study was to modulate macrophage polarity from the pro-inflammatory M1 to anti-inflammatory M2 phenotype using plasmid DNA (pDNA) expressing interleukin-4 (IL4) or interleukin-10 (IL10)-encapsulated in hyaluronic acid-poly(ethyleneimine) (HA-PEI) nanoparticles (NPs). The HA-PEI/p...

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發表在:Sci Rep
Main Authors: Tran, Thanh-Huyen, Rastogi, Ruchir, Shelke, Juili, Amiji, Mansoor M.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649614/
https://ncbi.nlm.nih.gov/pubmed/26577684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16632
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