Ligand-activated peroxisome proliferator-activated receptor-δ and -γ inhibit lipopolysaccharide-primed release of high mobility group box 1 through upregulation of SIRT1

Peroxisome proliferator-activated receptors (PPARs) inhibit lipopolysaccharide (LPS)-primed release of high mobility group box 1 (HMGB1), a late proinflammatory mediator, but the underlying molecular mechanism is not completely understood. In this study, we demonstrated that the inhibition of HMGB1...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Hwang, J S, Lee, W J, Kang, E S, Ham, S A, Yoo, T, Paek, K S, Lim, D S, Do, J T, Seo, H G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649513/
https://ncbi.nlm.nih.gov/pubmed/25275593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.406
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