Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor

In inflammatory processes, the p38 mitogen-activated protein kinase (MAPK) signal transduction route regulates production and expression of cytokines and other inflammatory mediators. Tumor necrosis factor α (TNF-α) is a pivotal cytokine in rheumatoid arthritis and its production in macrophages is u...

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Detalhes bibliográficos
Main Authors: Westra, Johanna, Doornbos-van der Meer, Berber, de Boer, Peter, van Leeuwen, Miek A, van Rijswijk, Martin H, Limburg, Pieter C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC464924/
https://ncbi.nlm.nih.gov/pubmed/15225374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1204
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