A phase 1 study of lenvatinib, multiple receptor tyrosine kinase inhibitor, in Japanese patients with advanced solid tumors

PURPOSE: This phase 1 study aimed to assess the tolerability, safety, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of lenvatinib capsules in Japanese patients with solid tumors when administered orally up to 24 mg on a once-daily (QD) continuous schedule. METHODS: Patients were...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Nakamichi, Shinji, Nokihara, Hiroshi, Yamamoto, Noboru, Yamada, Yasuhide, Honda, Kazunori, Tamura, Yosuke, Wakui, Hiroshi, Sasaki, Tatsuya, Yusa, Wataru, Fujino, Katsuki, Tamura, Tomohide
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648947/
https://ncbi.nlm.nih.gov/pubmed/26530955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2899-0
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