P16/INK4A up-regulation mediated by SIX6 defines retinal ganglion cell pathogenesis in glaucoma

Glaucoma, a blinding neurodegenerative disease, whose risk factors include elevated intraocular pressure (IOP), age and genetics, is characterized by accelerated and progressive retinal ganglion cell (RGC) death. Despite decades of research, the mechanism of RGC death in glaucoma is still unknown. H...

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I publikationen:Mol Cell
Huvudupphovsmän: Skowronska-Krawczyk, Dorota, Zhao, Ling, Zhu, Jie, Weinreb, Robert N., Luo, Jing, Flagg, Ken, Patel, Sherrina, Wen, Cindy, Krupa, Martin, Luo, Hongrong, Ouyang, Hong, Lin, Danni, Wang, Wengqiu, Li, Gen, Xu, Yanxin, Cao, Guiqun, Li, Oulan, Chung, Christopher, Yeh, Emily, Jafari, Maryam, Ai, Michael, Zhong, Zheng, Shi, William, Zheng, Lianghong, Krawczyk, Michal, Chen, Daniel, Shi, Catherine, Zin, Carolyn, Zhu, Jin, Mellon, Pamela L., Gao, Weiwei, Zhang, Liangfang, Sun, Xiaodong, Zhong, Sheng, Zhuo, Yehong, Rosenfeld, Michael G., Liu, Yizhi, Zhang, Kang
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648709/
https://ncbi.nlm.nih.gov/pubmed/26365380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.07.027
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