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Sugar–Protein Connectivity Impacts on the Immunogenicity of Site-Selective Salmonella O-Antigen Glycoconjugate Vaccines
A series of glycoconjugates with defined connectivity were synthesized to investigate the impact of coupling Salmonella typhimurium O-antigen to different amino acids of CRM(197) protein carrier. In particular, two novel methods for site-selective glycan conjugation were developed to obtain conjugat...
שמור ב:
הוצא לאור ב: | Angew Chem Int Ed Engl |
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Main Authors: | , , , , , , , , , , , , , , |
פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
WILEY-VCH Verlag
2015
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4648054/ https://ncbi.nlm.nih.gov/pubmed/26350581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201506112 |
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