Sugar–Protein Connectivity Impacts on the Immunogenicity of Site-Selective Salmonella O-Antigen Glycoconjugate Vaccines

A series of glycoconjugates with defined connectivity were synthesized to investigate the impact of coupling Salmonella typhimurium O-antigen to different amino acids of CRM(197) protein carrier. In particular, two novel methods for site-selective glycan conjugation were developed to obtain conjugat...

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Detalles Bibliográficos
Publicado en:Angew Chem Int Ed Engl
Autores principales: Stefanetti, Giuseppe, Hu, Qi-Ying, Usera, Aimee, Robinson, Zack, Allan, Martin, Singh, Alok, Imase, Hidetomo, Cobb, Jennifer, Zhai, Huili, Quinn, Douglas, Lei, Ming, Saul, Allan, Adamo, Roberto, MacLennan, Calman A, Micoli, Francesca
Formato: Artigo
Lenguaje:Inglês
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648054/
https://ncbi.nlm.nih.gov/pubmed/26350581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201506112
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