Combined effects of a high-fat diet and chronic valproic acid treatment on hepatic steatosis and hepatotoxicity in rats

AIM: To investigate the potential interactive effects of a high-fat diet (HFD) and valproic acid (VPA) on hepatic steatosis and hepatotoxicity in rats. METHODS: Male SD rats were orally administered VPA (100 or 500 mg·kg(−1)·d(−1)) combined with HFD or a standard diet for 8 weeks. Blood and liver sa...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Zhang, Li-fang, Liu, Ling-sheng, Chu, Xiao-man, Xie, Hao, Cao, Li-juan, Guo, Cen, A, Ji-ye, Cao, Bei, Li, Meng-jie, Wang, Guang-ji, Hao, Hai-ping
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647887/
https://ncbi.nlm.nih.gov/pubmed/24442146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.135
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