SNPs at miR-155 binding sites of TYRP1 explain discrepancy between mRNA and protein and refine TYRP1 prognostic value in melanoma

BACKGROUND: We previously demonstrated an inverse correlation between tyrosinase-related protein 1 (TYRP1) mRNA expression in melanoma metastases and patient survival. However, TYRP1 protein was not detected in half of tissues expressing mRNA and did not correlate with survival. Based on a study rep...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: El Hajj, P, Gilot, D, Migault, M, Theunis, A, van Kempen, L C, Salés, F, Fayyad-Kazan, H, Badran, B, Larsimont, D, Awada, A, Bachelot, L, Galibert, M-D, Ghanem, G, Journe, F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647532/
https://ncbi.nlm.nih.gov/pubmed/26068396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.194
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