Vorinostat Enhances Cytotoxicity of SN-38 and Temozolomide in Ewing Sarcoma Cells and Activates STAT3/AKT/MAPK Pathways

Histone deacetylase inhibitors (HDACi) have been evaluated in patients with Ewing sarcoma (EWS) but demonstrated limited activity. To better understand the potential for HDACi in EWS, we evaluated the combination of the HDACi vorinostat, with DNA damaging agents SN-38 (the active metabolite of irino...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sampson, Valerie B., Vetter, Nancy S., Kamara, Davida F., Collier, Anderson B., Gresh, Renee C., Kolb, E. Anders
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646493/
https://ncbi.nlm.nih.gov/pubmed/26571493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142704
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