Structural Basis for Substrate Specificity in Adenosylcobalamin-dependent Isobutyryl-CoA Mutase and Related Acyl-CoA Mutases

Acyl-CoA mutases are a growing class of adenosylcobalamin-dependent radical enzymes that perform challenging carbon skeleton rearrangements in primary and secondary metabolism. Members of this class of enzymes must precisely control substrate positioning to prevent oxidative interception of radical...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Jost, Marco, Born, David A., Cracan, Valentin, Banerjee, Ruma, Drennan, Catherine L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646380/
https://ncbi.nlm.nih.gov/pubmed/26318610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676890
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