High Resolution Structures of the Human ABO(H) Blood Group Enzymes in Complex with Donor Analogs Reveal That the Enzymes Utilize Multiple Donor Conformations to Bind Substrates in a Stepwise Manner

Homologous glycosyltransferases α-(1→3)-N-acetylgalactosaminyltransferase (GTA) and α-(1→3)-galactosyltransferase (GTB) catalyze the final step in ABO(H) blood group A and B antigen synthesis through sugar transfer from activated donor to the H antigen acceptor. These enzymes have a GT-A fold type w...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Gagnon, Susannah M. L., Meloncelli, Peter J., Zheng, Ruixiang B., Haji-Ghassemi, Omid, Johal, Asha R., Borisova, Svetlana N., Lowary, Todd L., Evans, Stephen V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646364/
https://ncbi.nlm.nih.gov/pubmed/26374898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.682401
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