Tau Aggregation Propensity Engrained in Its Solution State

[Image: see text] A peptide fragment of the human tau protein which stacks to form neat cross β-sheet fibrils, resembling that found in pathological aggregation, (273)GKVQIINKKLDL(284) (here “R2/WT”), was modified with a spin-label at the N-terminus. With the resulting peptide, R2/G273C-SL, we probe...

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Udgivet i:J Phys Chem B
Main Authors: Eschmann, Neil A., Do, Thanh D., LaPointe, Nichole E., Shea, Joan-Emma, Feinstein, Stuart C., Bowers, Michael T., Han, Songi
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2015
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645975/
https://ncbi.nlm.nih.gov/pubmed/26484390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.5b08092
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