Exclusive Decoration of Simian Immunodeficiency Virus Env with High-Mannose Type N-Glycans Is Not Compatible with Mucosal Transmission in Rhesus Macaques

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) envelope (Env) proteins are extensively decorated with N-glycans, predominantly of the high-mannose type. However, it is unclear how high-mannose N-glycans on Env impact viral spread. We show that exclusive modification of SI...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Karsten, Christina B., Buettner, Falk F. R., Cajic, Samanta, Nehlmeier, Inga, Neumann, Berit, Klippert, Antonina, Sauermann, Ulrike, Reichl, Udo, Gerardy-Schahn, Rita, Rapp, Erdmann, Stahl-Hennig, Christiane, Pöhlmann, Stefan
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Virus-Cell Interactions
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645679/
https://ncbi.nlm.nih.gov/pubmed/26355090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01358-15
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