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Epstein-Barr Viruses (EBVs) Deficient in EBV-Encoded RNAs Have Higher Levels of Latent Membrane Protein 2 RNA Expression in Lymphoblastoid Cell Lines and Efficiently Establish Persistent Infections in Humanized Mice

Functions of Epstein-Barr virus (EBV)-encoded RNAs (EBERs) were tested in lymphoblastoid cell lines containing EBER mutants of EBV. Binding of EBER1 to ribosomal protein L22 (RPL22) was confirmed. Deletion of EBER1 or EBER2 correlated with increased levels of cytoplasmic EBV LMP2 RNA and with small...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Gregorovic, Goran, Boulden, Elizabeth A., Bosshard, Rachel, Elgueta Karstegl, Claudio, Skalsky, Rebecca, Cullen, Bryan R., Gujer, Cornelia, Rämer, Patrick, Münz, Christian, Farrell, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645642/
https://ncbi.nlm.nih.gov/pubmed/26339045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01873-15
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