Excess Linoleic Acid Increases Collagen I/III Ratio and “Stiffens” the Heart Muscle Following High Fat Diets

Controversy exists on the benefits versus harms of n-6 polyunsaturated fatty acids (n-6 PUFA). Although n-6 PUFA demonstrates anti-atherosclerotic properties, survival following cardiac remodeling may be compromised. We hypothesized that n-6 PUFA like linoleic acid (LA) or other downstream PUFAs lik...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Beam, Julianne, Botta, Amy, Ye, Jiayu, Soliman, Hesham, Matier, Brieanne J., Forrest, Mary, MacLeod, Kathleen M., Ghosh, Sanjoy
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Lipids
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645600/
https://ncbi.nlm.nih.gov/pubmed/26240151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.682195
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