A Mutation in Transmembrane Domain 7 (TM7) of Excitatory Amino Acid Transporters Disrupts the Substrate-dependent Gating of the Intrinsic Anion Conductance and Drives the Channel into a Constitutively Open State

In the mammalian central nervous system, excitatory amino acid transporters (EAATs) are responsible for the clearance of glutamate after synaptic release. This energetically demanding activity is crucial for precise neuronal communication and for maintaining extracellular glutamate concentrations be...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Torres-Salazar, Delany, Jiang, Jie, Divito, Christopher B., Garcia-Olivares, Jennie, Amara, Susan G.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2015
Sujets:
Molecular Biophysics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645584/
https://ncbi.nlm.nih.gov/pubmed/26203187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.660860
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