A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide

Anti-hepatitis B virus (HBV) drugs are currently limited to nucleos(t)ide analogs (NAs) and interferons. A challenge of drug development is the identification of small molecules that suppress HBV infection from new chemical sources. Here, from a fungus-derived secondary metabolite library, we identi...

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Vydáno v:J Virol
Hlavní autoři: Kaneko, Manabu, Watashi, Koichi, Kamisuki, Shinji, Matsunaga, Hiroki, Iwamoto, Masashi, Kawai, Fumihiro, Ohashi, Hirofumi, Tsukuda, Senko, Shimura, Satomi, Suzuki, Ryosuke, Aizaki, Hideki, Sugiyama, Masaya, Park, Sam-Yong, Ito, Takayoshi, Ohtani, Naoko, Sugawara, Fumio, Tanaka, Yasuhito, Mizokami, Masashi, Sureau, Camille, Wakita, Takaji
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645323/
https://ncbi.nlm.nih.gov/pubmed/26378168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01855-15
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