Dzip3 regulates developmental genes in mouse embryonic stem cells by reorganizing 3D chromatin conformation

In mouse embryonic stem (mES) cells, ubiquitylation of histone H2A lysine 119 represses a large number of developmental genes and maintains mES cell pluripotency. It has been suggested that a number of H2A ubiquitin ligases as well as deubiquitylases and related peptide fragments contribute to a del...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Inoue, Daishi, Aihara, Hitoshi, Sato, Tatsuharu, Mizusaki, Hirofumi, Doiguchi, Masamichi, Higashi, Miki, Imamura, Yuko, Yoneda, Mitsuhiro, Miyanishi, Takayuki, Fujii, Satoshi, Okuda, Akihiko, Nakagawa, Takeya, Ito, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645096/
https://ncbi.nlm.nih.gov/pubmed/26568260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16567
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