Treatment of Cholestatic Fibrosis by Altering Gene Expression of Cthrc1: Implications for Autoimmune and non-Autoimmune Liver Disease

Collagen triple helix repeat containing-1 (Cthrc1) is a documented specific inhibitor of TGF-β signaling. Based on this observation, we developed the hypothesis that knocking in/knocking out the Cthrc1 gene in murine models of cholestasis would alter the natural history of cholestatic fibrosis. To s...

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Veröffentlicht in:J Autoimmun
Hauptverfasser: Bian, Zhaolian, Miao, Qi, Zhong, Wei, Zhang, Haiyan, Wang, Qixia, Peng, Yanshen, Chen, Xiaoyu, Guo, Canjie, Shen, Li, Yang, Fan, Xu, Jie, Qiu, Dekai, Fang, Jingyuan, Friedman, Scott, Tang, Ruqi, Gershwin, M. Eric, Ma, Xiong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644665/
https://ncbi.nlm.nih.gov/pubmed/26238209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2015.07.010
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