Go mediates the coupling of the mu opioid receptor to adenylyl cyclase in cloned neural cells and brain.
In membranes from SH-SY5Y human neuroblastoma cells differentiated with retinoic acid, the mu-selective agonist Tyr-D-Ala-Gly-N-Me-Phe-Gly-ol (DAMGO) inhibited cAMP formation with an IC50 of 26 nM. Two separate antibodies raised against distinct regions of the Go alpha sequence attenuated the effect...
Enregistré dans:
| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
1993
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46446/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8097884/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.9.4062 |
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