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Transcriptomic Heterogeneity in Cancer as a Consequence of Dysregulation of the Gene–Gene Interaction Network

Many pathways are dysregulated in cancer. Dysregulation of the regulatory network results in less control of transcript levels in the cell. Hence, dysregulation is reflected in the heterogeneity of the transcriptome: the more dysregulated the pathway, the more the transcriptomic heterogeneity. We id...

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Detalhes bibliográficos
Publicado no:Bull Math Biol
Main Authors: van Wieringen, Wessel N., van der Vaart, Aad W.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644214/
https://ncbi.nlm.nih.gov/pubmed/26376888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11538-015-0103-7
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