Rapid Macrocycle Threading by a Fluorescent Dye-Polymer Conjugate in Water with Nanomolar Affinity

A macrocyclic tetralactam host is threaded by a highly fluorescent squaraine dye that is flanked by two polyethyleneglycol (PEG) chains with nanomolar dissociation constants in water. Furthermore, the rates of bimolecular association are very fast with k(on) ~10(6)–10(7) M(−1)s(−1). The association...

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Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Peck, Evan M., Liu, Wenqi, Spence, Graeme T., Shaw, Scott K., Davis, Anthony P., Destecroix, Harry, Smith, Bradley D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643739/
https://ncbi.nlm.nih.gov/pubmed/26106948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b03573
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