Fibronectin fragment-induced expression of matrix metalloproteinases is mediated by MyD88-dependent TLR-2 signaling pathway in human chondrocytes

INTRODUCTION: Fibronectin fragments (FN-fs) are increased in the cartilage of patients with osteoarthritis (OA) and have a potent chondrolytic effect. However, little is known about the cellular receptors and signaling mechanisms that are mediated by FN-fs. We investigated whether the 29-kDa amino-t...

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Vydáno v:Arthritis Res Ther
Hlavní autoři: Hwang, Hyun Sook, Park, Su Jin, Cheon, Eun Jeong, Lee, Mi Hyun, Kim, Hyun Ah
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4643537/
https://ncbi.nlm.nih.gov/pubmed/26563875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0833-9
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